Fig. 4. The TF repertoires of monocytes and derived macrophages. (A)
Bar representation of the TF family members that are expressed in at least
one of the four cell samples (Mo, Mf, LPS-Mf, and BG-Mf). The number of
TFs with RPKM values > 2 is plotted, and the total number of TF family
members in humans is indicated between brackets. (B and C) Heat map of
the expression levels (log2 RPKM) of TFs that change expression at least
4-fold in at least one of the four conditions examined. TFs are grouped
according to families and whether they are up- or down-regulated upon
differentiation. Scale (left) indicates the level of expression (log2 RPKM).
(D) Hierarchical clustering of the TF motif occurrence frequency (log2
percentage, scale at top) in each ACe cluster–associated DHS from all TF
motifs that have more than 5% occurrence in at least one instance and that
are overrepresented in at least one of the ACe clusters compared with all
nondynamic acetylated regions (hypergeometric test, P < 0.01).
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