22 SEPTEMBER 2017 • VOL 357 ISSUE 6357 1211 SCIENCE sciencemag.org
CONTENTS 1261 Avoiding self-poisoning
22 SEPTEMBER 2017 • VOLUME 357 • ISSUE 6357
1266 COSMIC RAYS
Observation of a large-scale anisotropy
in the arrival directions of cosmic rays
above 8 × 1018 eV
The Pierre Auger Collaboration
▶ PERSPECTIVE P. 1240; PODCAST
Titanium isotopic evidence for felsic
crust and plate tectonics 3.5 billion
years ago N. D. Greber et al.
1274 ULTRAFAST OPTICS
Angular momentum–induced delays in
solid-state photoemission enhanced by
intra-atomic interactions F. Siek et al.
▶ PERSPEC TIVE P. 1239
The hidden simplicity of subduction
M.-A. Meier et al.
The growth pattern of Neandertals,
reconstructed from a juvenile skeleton
from El Sidrón (Spain) A. Rosas et al.
Teaching personal initiative beats
traditional training in boosting small
business in West Africa F. Campos et al.
1290 COGNITIVE DEVELOPMENT
Infants make more attempts to achieve
a goal when they see adults persist
J. A. Leonard et al.
▶ PERSPEC TIVE P. 1236
PAF1 regulation of promoter-proximal
pause release via enhancer activation
F. X. Chen et al.
1299 RNA LOCALIZATION
Global mRNA polarization regulates
translation efficiency in the intestinal
epithelium A. E. Moor et al.
▶ PERSPECTIVE P. 1235
1303 GENOME ENGINEERING
Inactivation of porcine endogenous
retrovirus in pigs using CRISPR-Cas9
D. Niu et al.
▶ PERSPECTIVE P. 1238
ON THE COVER
A 2-week-old piglet
whose genome has been
engineered to inactivate
This animal is from a
cell line created using
CRISPR technology to
inactivate PERVs, the
possible transmission of which has hindered
effective xenotransplantation. This work
addresses safety concerns about cross-
species viral transmission and brings us one
step closer to reliable pig-to-human organ
transplants. See pages 1238 and 1303.
Photo: K. Fan/eGenesis
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DEPAR TMEN TS
Refilling the coral reef glass
By David Obura
1322 WORKING LIFE
Sunshine outside the ivory tower
By Amanda Welch et al.
Science Staff ............................................. 1214
Gordon Research Conferences ............... 1308
New Products............................................ 1317
Science Careers ........................................ 1319
1248 EDITORIAL EXPRESSION OF CONCERN
By J. Berg
1248 SAVING THE SAOLA FROM EXTINCTION
By A. Tilker et al.
1248 ADDRESSING SCIENTIFIC INTEGRITY
By T. Mayer et al.
1249 NORTH KOREA BAN BLOCKS
By T. Kim
1250 From Science and other journals
1253 CELLULAR BIOPHYSICS
Liquid phase condensation in cell
physiology and disease
Y. Shin and C. P. Brangwynne
REVIEW SUMMARY; FOR FULL TEXT:
Loss of a mammalian circular RNA locus
causes miRNA deregulation and affects
brain function M. Piwecka et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
1255 PARKINSON’S DISEASE
Dopamine oxidation mediates
mitochondrial and lysosomal dysfunction
in Parkinson’s disease
L. F. Burbulla et al.
1261 MOLECULAR EVOLUTION
Interacting amino acid replacements
allow poison frogs to evolve epibatidine
resistance R. D. Tarvin et al.