Probing Cancer Pathways
How Chemical Biology Can Inform
May 3, 2011
12 noon ET, 9 am PT,
4 pm GMT, 5 UK
Leonard Zon, M.D.
and Harvard Medical School
Hakim Djaballah, Ph.D.
New York, NY
Gregory Verdine, Ph.D.
During normal growth and differentiation,
maintaining the appropriate homeostatic balance in
a cell is paramount. This fundamental level of control
is achieved through the interaction of small molecule
chemical modulators with those proteins involved in
cellular signaling. Researchers can take advantage
of these regulatory interactions to study signaling
pathways, for instance by designing chemicals that
reverse the hyper-proliferation phenotype seen in
many cancers. These small molecules can be used
both as tools to interrogate a particular pathway and
as precursors for drug development. This webinar
will provide an overview of how chemical biology
can be used in various model systems to both
advance our understanding of basic cell signaling
mechanisms as well as aid in the discovery of novel
small molecule therapeutics for cancer.
During this webinar, the panelists will:
• Provide an overview of how chemical biology can
impact cancer research
• Describe their own research using small
molecules to elucidate signaling pathways and
characterize their component proteins
• Give you the opportunity to ask them questions,
live and in real time.
Brought to you by the
AAAS/Science Business Office
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