Massive CO2 Ice Deposits Sequestered in the
South Polar Layered Deposits of Mars
R. J. Phillips et al.
Radar measurements reveal a substantial buried
deposit of CO2 in the south pole of Mars.
>> Science Podcast
Cold-Trapping Mars’ Atmosphere
P. C. Thomas
Impact of Polar Ozone Depletion
on Subtropical Precipitation
S. M. Kang et al.
The Antarctic ozone hole has led to increased
summertime precipitation in the subtropics
of the Southern Hemisphere.
Comparative Functional Genomics
of the Fission Yeasts
N. Rhind et al.
A combined analysis of genome sequence,
structure, and expression gives insights
into fission yeast biology.
The Toll-Like Receptor 2 Pathway Establishes
Colonization by a Commensal of the Human
J. L. Round et al.
Signaling through innate immune receptors promotes
commensal bacteria colonization of the gut.
Spatial Coupling of m TOR and Autophagy
Augments Secretory Phenotypes
M. Narita et al.
A cellular compartment allows simultaneous protein
synthesis and degradation.
Highlights From Our Daily News Coverage
CREDI T: SÉVERINE PFIRSCH-MAISONNAS/INSERM/PARIS, FRANCE
Hospitals Engaging in Risky Use
of Clotting Drug
Analyses find that off-label use of rFVIIa
may hurt patients.
Mass Killings of Gazelles Marked Rise
of Human Civilization
Scientists find evidence that animals
were slaughtered in long stone traps.
How Much Did the Dodo Really Weigh?
Researchers engage in a battle of the bulge
over the long-extinct bird.
The Signal Transduction Knowledge Environment
19 April issue: http://scim.ag/ss041911
RESEARCH ARTICLE: Inhibitory ITAM Signaling
Traps Activating Receptors with the Phosphatase
SHP-1 to Form Polarized “Inhibisome” Clusters
S. Pfirsch-Maisonnas et al.
PERSPECTIVE: How ITAMs Inhibit Signaling
L. B. Ivashkiv
Receptors with activating motifs are captured in
inhibitory intracellular compartments and thereby
prevented from signaling.
RESEARCH ARTICLE: ERKs Induce Expression
of the Transcriptional Repressor Blimp-1 and
Subsequent Plasma Cell Differentiation
T. Yasuda et al.
PERSPECTIVE: pERKing Up the BLIMP in Plasma
D. M. Allman and M. P. Cancro
The differentiation of B cells into antibody-producing
plasma cells requires extracellular signal–regulated
Analyze mass spectrometry data and compare your
results to published data sets; in Protein Databases.
NETWATCH: The Virtual Cell
Build models and run simulations of cell biological
processes; in Modeling Tools.
Free Career Resources for Scientists
Experimental Error: Forging a Head
Scientific hoaxes can be fun (when they are
harmless) while also serving a serious function:
exposing failures of scientists’ most important
tool, their skepticism.
Finding a Niche in Food and Health Research
Three researchers on food and health describe how
they developed careers in the field.
SCIENCE TRANSLATIONAL MEDICINE
Integrating Medicine and Science
20 April issue: http://scim.ag/stm042011
EDITORIAL: Gene Therapy for Parkinson’s Disease
A. Björklund and T. Björklund
A gene therapy trial for Parkinson’s disease met its
primary endpoint, but challenges remain.
PERSPECTIVE: HIV-1 Vaccines and
Adaptive Trial Designs
L. Corey et al.
Development of an HIV vaccine could be accelerated
by testing candidate vaccines using adaptive clinical
Sequestered in an inhibisome.
PERSPECTIVE: Biomarkers for Parkinson’s Disease
T. B. Sherer
Identifying much-needed biomarkers for
detecting early Parkinson’s disease will
accelerate drug development.
REPORT: Electronic Medical Records for Genetic
Research—Results of the eMERGE Consortium
A. N. Kho et al.
Clinical data captured in electronic medical
records accurately identify cases and controls
for genome-wide association studies.
RESEARCH ARTICLE: The Fate and Toxicity of
Raman-Active Silica-Gold Nanoparticles in Mice
A. S. Thakor et al.
Gold-core nanoparticles designed for imaging
by Raman spectroscopy in patients are generally
nontoxic in mice.
Free Weekly Show
On the 22 April Science Podcast: large deposits
of frozen CO2 on Mars, cheaper high-performance
fuel cell catalysts, cleaning up the Ganges River,
Science Policy News and Analysis
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