Phenotyping Core, UT Southwestern Medical Center) for excellent
technical assistance with animal studies. Author contributions:
Y.D. conceived the study, designed and performed the
experiments, and analyzed data; Z.V. W. helped with uridine
clearance study and tolerance tests; R.G. performed uridine
analysis with HPLC-MS/MS; Y.A. performed the studies using the
FAT-ATTAC mice; K.M.C. performed studies using the Agpat2 KO
mice; C.Z. helped with gallbladder and tissue collection; Q.L. and
J.D.B. synthesized PALA; J. Y. and S.K. provided the human
samples and contributed to the discussion; J.K.E. and J.D.H.
contributed to the discussion; J.A.H. contributed to the discussion
and edited the manuscript; P.E.S. conceived the study; and Y.D.
and P.E.S. wrote the manuscript with suggestions from all authors.
Supported by American Diabetes Association postdoctoral
fellowship 7-08-MN-53 (Y.D.), American Heart Association scientist
development grant 14SDG18440002 (Z.V. W.), NIH grants R01-
DK55758 and R01-DK099110 (P.E.S.), NIH grant P01DK088761
(P.E.S., J.K.E., J.D.H.), NIH grant R01-DK101578 (S.K.), Robert A.
Welch Foundation grant I-1422 (J.D.B.), and American Heart
Association grant 14SFRN20740000 and NIH grants HL-120732,
HL-100401, and HL-126012 (J.A.H.). The authors have no
conflicting financial interests.
Figs. S1 to S4
Tables S1 and S2
24 February 2016; accepted 17 January 2017