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TECHNICAL COMMENT ABSTRACTS
Comment on “Molecular and neural basis
of contagious itch behavior in mice”
Jaquette Liljencrantz, Mark H. Pitcher,
Lucie A. Low, Lucy Bauer,
M. Catherine Bushnell
Yu et al. (Reports, 10 March 2017, p. 1072)
state that contagious itch occurs in mice
based on imitative scratching in normal mice
observing excessive scratching in genetically modified demonstrator mice. However,
despite employing multiple behavioral analysis approaches, we were unable to extend
these findings to normal mice observing the
well-established histamine model of acute
itch in demonstrator mice.
Full text: // dx.doi.org/10.1126/science.aan4749
Response to Comment on “Molecular and
neural basis of contagious itch behavior
Devin M. Barry, Yao-Qing Yu, Yan Hao,
Xue-Ting Liu, Zhou-Feng Chen
Liljencrantz et al. report the failure of observing contagious itch behavior using mice
injected with histamine as the demonstrators. Analysis of their results shows that the
histamine model is limited by inadequate
frequency and duration of scratching bouts
required for contagious itch test. To streamline the contagious itch test, the screen
paradigm is highly recommended.
Full text: // dx.doi.org/10.1126/science.aan5000
Erratum for the Research Article “Anticancer
sulfonamides target splicing by inducing RBM39 degradation via recruitment
to DCAF15” by T. Han et al., Science 356,
eaan7977 (2017). Published online 26 May