32 & 83
Signals from the
lysosome regulate aging
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Science Staff .................................................. 6
New Products ............................................... 87
Science Careers ........................................... 88
38 From Science and other journals
41 2D MATERIALS
Graphene, related two-dimensional
crystals, and hybrid systems for
energy conversion and storage
F. Bonaccorso et al.
REVIEW SUMMARY; FOR FULL TEX T:
42 Extensive introgression in a
malaria vector species complex
revealed by phylogenomics
M. C. Fontaine et al.
RESEARCH ARTICLE SUMMARY; FOR FULL
43 Highly evolvable malaria vectors:
The genomes of 16 Anopheles
mosquitoes D. E. Neafsey et al.
RESEARCH ARTICLE SUMMARY; FOR FULL
▶ PERSPECTIVE P. 27
44 STRUCTURAL BIOLOGY
Mechanistic insight from the crystal
structure of mitochondrial complex I
V. Zickermann et al.
49 ORGANIC CHEMISTRY
chemistry for the synthesis of
A. Buitrago Santanilla et al.
53 QUANTUM OPTICS
Quantum harmonic oscillator state
synthesis by reservoir engineering
D. Kienzler et al.
56 ORGANIC CHEMISTRY
Rh-catalyzed C–C bond cleavage
by transfer hydroformylation
S. K. Murphy et al.
▶ PERSPEC TIVE P. 29
60 REACTION DYNAMICS
Extremely short-lived reaction
resonances in Cl + HD (v = 1) → DCl + H
due to chemical bond softening
T. Yang et al.
63 BACTERIAL EVOLUTION
The type VI secretion system of Vibrio
cholerae fosters horizontal gene transfer
S. Borgeaud et al.
67 INNATE IMMUNITY
Dermal adipocytes protect against
invasive Staphylococcus aureus skin
infection L. Zhang et al.
▶ PERSPEC TIVE P. 26
71 VIRUS STRUCTURE
Structure and inhibition of EV-D68, a
virus that causes respiratory illness in
children Y. Liu et al.
75 PROTEIN SYNTHESIS
Rqc2p and 60S ribosomal subunits
mediate mRNA-independent elongation
of nascent chains P. S. Shen et al.
78 CANCER ETIOLOGY
Variation in cancer risk among
tissues can be explained by the number
of stem cell divisions
C. Tomasetti and B. Vogelstein
▶ NEWS STORY P. 12
Smoking is associated with
mosaic loss of chromosome Y
J. P. Dumanski et al.
Lysosomal signaling molecules regulate
longevity in Caenorhabditis elegans
A. Folick et al.
▶ PERSPEC TIVE P. 32
ON THE COVER
of the mouthparts of
a female Anopheles
Sheathed in a scaly
lower lip ending in two
hairy lobes (blue) are
a pair of saw-toothed
stylets (green) used to cut into the skin.
Because only female Anopheles blood feed,
only females transmit malaria—a disease
that claims the lives of more than half a
million children each year. See pages 27, 42,
and 43. Image: Science Photo Library
By Marcia McNutt
98 WORKING LIFE
My liberation through science
By Mary Poffenroth